Use ASSIC Performance Fingerprint to upload and monitor your health parameters
Biology
- Most likely source of virus infection originated from transition from Pangolins to Humans and subsequent spread from human to human
- Infection can be spread by asymptomatic carriers
- Viral particles enter in lungs via droplet infection. Other modes of infection unclear
Epidemiology:
- Typical incubation time 4-14 days (up to 24 days)
- China notified WHO 31-12-2019
- WHO declared pandemic 11-03-2020
At risk:
- Congregations of people
- Areas of infections
Symptoms
- Cough (65-80%)
- Fever (45%)
- Shortness of breath (20-40%)
- Upper respiratory tract symptoms (15%)
- Gastrointestinal symptoms (10%)
Monitor relevant Vitals
- Temperature
- Heart rate and BP
- Respiratory rate
Laboratory investigations
- Decreased WCC and lymphopaenia
- Increase BUN/Cr
- LFTs: increase in AST/ALT/Tbil
- Increase D-dimer
- Increase CRP
- Increase LDH
- Decrease Procalcitonin (if secondary bacterial infection it will be elevated)
- PCR COVID-19 test
Chest X-ray
- Hazy bilateral peripheral opacities on chest X-ray
- CT scan: ground glass opacities, consolidation
Treatment
Prevention
- Prevent infection with necessary precautions
- Hand cleaning: 20+ seconds with soap and water or preferably alcohol based solution
- Isolate/Quarantine
Anti flu viral medication and anti retroviral medication being used. Treatment experimental presently. Guidelines to follow.
- Remdesivir: anti RNA polymerase
- Chloroquine: blocks virus entry into endosome
- Tocilizumab: block IL-6
Supportive treatment
- Avoid anti-inflammatory medication (NSAID)
- Respiratory failure management
- Adequate nutrition
- Prolonged bed rest: Deep Vein Thrombosis (DVT) exercise routine to prevent DVT and pulmonary embolism complications
Mortality associated with:
- Elderly
- Immunocompromised individulas: examples include HIV/Oncology patients
- Medical conditions: Diabetes, Chronic Obstructive Airways Disease
Laboratory predictors of poor outcome:
- Increase D dimer
- Increase ferritin
- Increase troponin
- Increase cardiac myoglobin
- Monitor secondary infection
Use ASSIC Performance Fingerprint to upload and monitor your health parameters
Precaution
- Glove protection
- N95 masks
- Hand hygiene:20 + seconds with soap and water or alcohol containing solution
